HomeNew producsSpecialsMy accountFAQContact Us
Search
 

Use keywords to find the product you are looking for.

 
Categories
PGD2 Inhibitors
Chromoglycate / Indomethacin A+B
D-Cloprostenol
PGD2 Inhibitor Data
Ramatroban
SARMs
Ostarine 25mg / ml, 60ml
SARMs S4 25mg / ml, 60ml
SERMs
Clomiphene 3000mg, 60ml
Raloxifene 60mg /ml, 60ml
Tamoxifen (True Twenty) 1200mg, 60ml
Toremifene Citrate 1800mg, 30ml
Toremifene Citrate 3600mg, 60ml
b2 ADRENERGENIC AGONISTS
Albuterol 6mg/ml, 60ml
Clenbuterol 200mcg/ml, 30ml
Clenbuterol 200mcg/ml, 60ml
THYROID RELATED
T3 100mcg / ml, 60ml
T4 400mcg / ml, 60ml
AROMATASE INHIBITORS
Anastrozole 30mg, 30ml
Anastrozole 60mg, 60ml
Exemestane 300mg, 30ml
Exemestane 600mg, 60ml
Letrozole 150mg, 60ml
Letrozole 75mg / 30ml
IGF-1 PEPTIDES
IGF-1 DES 1 3, 1200mcg
IGF-1 Lr3 (10 vials)
IGF-1 Lr3 (3 Vials)
IGF-1 Lr3, 1200mcg
IGF-1 RH, 1200mcg
IGF-2 Lr3 1200mcg
MGF (IGF-1Ec) 2000mcg
IGF KITS
IGF-1 DES 1 3 KIT Receptor 1200mcg
IGF-1 Lr3 KIT Receptor 1200mcg
IGF-2 Lr3 Kit Receptor 1200mcg
MELANOTROPIN PEPTIDES
Melanotan II (10 vials) 100mg
Melanotan II 10mg
Melanotan II 30mg (3 Vials)
PT-141 (Bremalanotide) 10mg
SECRETOGOGUE PEPTIDES
CJC 1295 DAC, 2000mcg
CJC 1295 DAC, 2000mcg (3 vials)
CJC-1293 (GRF [1 29]) (3 vials)
CJC-1293 (GRF [1-29]) 2000mcg
GHRP-2 (4 Vials)
GHRP-2 (receptor) 5mg
GHRP-6 (receptor), 5mg
GHRP-6, (4 vials)
GnRH, 2000mcg
Hexarelin, 2000mcg
Ipamorelin, 2000mcg
Tesamorelin, 5 vial kit, 10mg
PEPTIDES
Ghrelex (D-Lys≥ GHRP-6)
Oxytocin, 1200iu
Phospho DSIP 1000mcg
Thymosin Beta 4, 8mg (4 vial pack)
MORE RESEARCH CHEM'S
AICAR 100mg
Dapoxetine HCL 30mg/ml, 30ml
GW1516, 150mg
Ketotifen Fumarate 120mg 60ml
Rimonabant 1200mg, 60ml
Yohimbine HCL, 10mg/ml, 30ml
SELECTIVE ANTI-ANDROGENS
Cortexolone 17-Alpha Propionate
Dutasteride 30mg, 60ml
Finasteride 150mg, 30ml
PDE5 INHIBITORS
Avanafil 50mg / ml, 60ml (Presale)
Sildenafil Citrate 750mg, 30ml
Tadalafil 30mg/ml, 30ml
Tadalafil 30mg/ml, 60ml
Vardenafil 300mg, 30ml
NOOTROPICS
Dihydroergotoxine (Ergotox)
Meclofenoxate, 60g
Pramiracetam 30g
Selegiline 300mg, 30ml
PROLACTIN ANTAGONISTS
Cabergoline 15mg, 30ml
Pramipexole Hydrochloride 60mg, 60ml
A.G.E. INHIBITORS / BREAKERS
ALT-711 (thiazolium chloride), 15g
Aminoguanidine HCL 4.5g, 60ml
TELOMERASE ACTIVATORS
Astragaloside IV 20mg / ml, 60ml
Cycloastragenol 5mg / ml, 60ml
HEPATOXICITY INHIBITORS
Silibinin 100mg/ml, 60ml
Ursodeoxycholic Acid, 30g
COMBINATION SPECIALS
AICAR + GW1516
Clen + Keto + Yohimbine
Tamox / Clom / Anast
MISCELLANEOUS
Custom Order: CO_061013NH
Expedited Service
Foreign Reship Fee
Legal Disclaimer for Download
Priority Shipping
Shipping Insurance $100-$299
Shipping Insurance $1000-$3000
Shipping Insurance $25-$99
Shipping Insurance $300-$599
Shipping Insurance $600-$999
Special Handling Fee $16
Special Handling Fee $30
test

AICAR 100mg

 [AR01]
 $98.00 
AICAR 100mg

AICAR

 

AICAR, aminoimidazole carboxamide ribonucleotide, acts as an agonist to AMP-activated protein kinase; AMP-activated protein kinase, also known as AMPK, is an enzyme with an important role in cellular homeostasis and energy regulation.[1]  AMPK acts through a variety of means to ultimately stimulate liver fatty oxidation, ketogenesis, beta-cell modulation of insulin secretion, and other functions within the body.  AICAR has been shown to stimulate glucose uptake and reduce apoptosis by reducing reactive oxygen compounds within cells.[2][3]

 

In a breakthrough study in 2008, Narkar et al of the Salk Institute discovered that AICAR significantly improves the performance of mice in endurance-type exercise by converting fast-twitch muscle fibers to the more energy-efficient, fat-burning, slow-twitch type. They also found that AICAR and GW1516, when given to "sedentary" mice, activated 40% of the genes that were turned on when mice were given GW1516 and made to exercise. As a result a publicity storm about "exercise pills" and "exercise in a pill" ensued.  The World Anti-Doping Agency now lists both compounds on their prohibited list (since 2009), and the lead researcher of the breakthrough study cooperated in providing data to make possible a urinalysis test to detect AICAR.[4][5]

 

AICAR has a number of other experimental/clinical and research chemical uses as it is expressed in a variety of tissue types.  Bai et al found that "data demonstrate that AICAR-initiated AMPK activation may represent a promising alternative to our current approaches to suppressing intestinal inflammation in IBD."[6]

 

Guo et al found "results suggest[ing] a mechanism by which AICAR inhibits the proliferation of EGFRvIII expressing glioblastomas and point toward a potential therapeutic strategy for targeting EGFR-activated cancers."[7]

 

An original study by Pold et al offers additional hope that AICAR could offer important treatment potential for humans:

 

Five-week-old, pre-diabetic ZDF rats underwent daily treadmill running or AICAR treatment over an 8-week period and were compared with an untreated group. In contrast to the untreated, both the exercised and AICAR-treated rats did not develop hyperglycemia during the intervention period. Whole-body insulin sensitivity, as assessed by a hyperinsulinemic-euglycemic clamp at the end of the intervention period, was markedly increased in the exercised and AICAR-treated animals compared with the untreated ZDF rats (P < 0.01). In addition, pancreatic beta-cell morphology was almost normal in the exercised and AICAR-treated animals, indicating that chronic AMPK activation in vivo might preserve beta-cell function. Our results suggest that activation of AMPK may represent a therapeutic approach to improve insulin action and prevent a decrease in beta-cell function associated with type 2 diabetes.[8]

 

Cititations:

[1]Corton JM, Gillespie JG, Hawley SA, Hardie DG. "5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?". Eur. J. Biochem. 229 (2): 558–65.  1995.

[2]Lemieux K, Konrad D, Klip A, Marette A. "The AMP-activated protein kinase activator AICAR does not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake and p38 mitogen-activated protein kinases alpha and beta in skeletal muscle". Faseb J. 17 (12): 1658–65. 2003.

[3]Kim JE, Kim YW, Lee IK, Kim JY, Kang YJ, Park SY.  "AMP-activated protein kinase activation by

5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) inhibits palmitate-induced endothelial cell apoptosis through reactive oxygen species suppression". J. Pharmacol. Sci. 106 (3): 394–403. 2008.

[4]Narkar VA, Downes M, Yu RT, Embler E, Wang YX, Banayo E, Mihaylova MM, Nelson MC, Zou Y, Juguilon H, Kang H, Shaw RJ, Evans RM. "AMPK and PPARdelta agonists are exercise mimetics". Cell 134 (3): 405–15. 2008. [5]WADA 2009 Prohibited List: WADA PROHIBITED LIST PDF (PDF Document).

[6]Bai A, Yong M, Ma Y, Ma A, Weiss C, Guan Q, Bernstein C, Peng Z. Novel Anti-Inflammatory Action of 5-Aminoimidazole-4-carboxamide ribonucleoside with protective effect in DSS-induced acute and chronic colitis. J Pharmacol Exp Ther. 2010 Mar 17.

[7]Guo D, Hildebrandt IJ, Prins RM, Soto H, Mazzotta MM, Dang J, Czernin J, Shyy JY, Watson AD, Phelps M, Radu CG, Cloughesy TF, Mischel PS.  The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis.Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12932-7.

[8]Pold R, Jensen LS, Jessen N, Buhl ES, Schmitz O, Flyvbjerg A, Fujii N, Goodyear LJ, Gotfredsen CF, Brand CL, Lund S. Long-term AICAR administration and exercise prevents diabetes in ZDF rats.  Diabetes. 2005 Apr;54(4):928-34.

 

*The latter article is intended for educational / informational purposes only. THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

This product was added to our catalog on Friday 16 October, 2009.
Reviews Add to Wish List
Quantity:     
Customers who bought this product also purchased
 
 
Shopping Cart
  Now in your cart 0 items
 
Your Account
 
Your Email Address
Your Password
 
Information
   
BestSellers
   
Featured
 
  GW1516, 150mg
 
 

GW1516, 150mg

$119.00
Comments

Write a review on this product!
Who's Online
  There currently are 19 guests and 
1 member online.