HomeNew producsSpecialsMy accountFAQContact Us
Search
 

Use keywords to find the product you are looking for.

 
Categories
PGD2 Inhibitors
D-Cloprostenol
Ramatroban 3mg/ml , 60ml
SARMs
Ostarine 25mg/ml , 60ml
SARMs S4 - 25mg/ml , 60ml
SERMs
Clomiphene 50mg/ml , 60ML
Raloxifene 60mg/ml , 60ML
Tamoxifen (True Twenty) 30.4mg/ml , 60ML
Toremifene Citrate 60mg/ml , 30ML
Toremifene Citrate 60mg/ml , 60ML
b2 ADRENERGENIC AGONISTS
Albuterol 6mg/ml, 60ML
Clenbuterol 200mcg/ml , 30ML
Clenbuterol 200mcg/ml , 60ML
THYROID RELATED
T3 100mcg/ml , 60ML
T4 400mcg/ml , 60ML
AROMATASE INHIBITORS
Anastrozole 1mg/ml , 30ML
Anastrozole 1mg/ml , 60ML
Exemestane 10mg/ml , 30ML
Exemestane 10mg/ml , 60ML
Letrozole 2.5mg/ml , 30ML
Letrozole 2.5mg/ml , 60ML
IGF-1 PEPTIDES
IGF-1 DES 1 3, 1200mcg
IGF-1 Lr3 (10 vials)
IGF-1 Lr3 (3 Vials)
IGF-1 Lr3, 1200mcg
IGF-1 RH, 1200mcg
IGF-2 Lr3 1200mcg
MGF (IGF-1Ec) 2000mcg
IGF KITS
IGF-1 DES 1 3 KIT Receptor 1200mcg
IGF-1 Lr3 KIT Receptor 1200mcg
IGF-2 Lr3 Kit Receptor 1200mcg
MELANOTROPIN PEPTIDES
Melanotan II (10 vials) 100mg
Melanotan II 10mg
Melanotan II 30mg (3 Vials)
PT-141 (Bremalanotide) 10mg
SECRETOGOGUE PEPTIDES
CJC 1295 DAC, 2000mcg
CJC 1295 DAC, 2000mcg (3 vials)
CJC-1293 (GRF [1 29]) (3 vials)
CJC-1293 (GRF [1-29]) 2000mcg
GHRP-2 (4 Vials)
GHRP-2 (receptor) 5mg
GHRP-6 (receptor), 5mg
GHRP-6, (4 vials)
GnRH, 2000mcg
Hexarelin, 2000mcg
Ipamorelin, 2000mcg
Tesamorelin, 5 vial kit, 10mg
PEPTIDES
Ghrelex (D-Lys≥ GHRP-6)
Oxytocin, 1200iu
Phospho DSIP 1000mcg
Thymosin Beta 4, 8mg (4 vial pack)
MORE RESEARCH CHEM'S
AICAR KIT 100mg
Dapoxetine HCL 30mg/ml , 30ml
GW1516 - 5mg/ml , 30ml
Ketotifen Fumarate 2mg/ml , 60ml
Rimonabant 20mg/ml , 60ml
Yohimbine HCL, 10mg/ml , 30ML
SELECTIVE ANTI-ANDROGENS
Cortexolone 17-Alpha Propionate
Finasteride 5mg/ml , 30ml
PDE5 INHIBITORS
Sildenafil Citrate 25mg/ml , 30ML
Tadalafil 30mg/ml , 30ML
Tadalafil 30mg/ml , 60ML
Vardenafil 10mg/ml , 30ML
NOOTROPICS
Dihydroergotoxine (Ergotox)
Meclofenoxate, 60g
Pramiracetam 30g
Selegiline 10mg/ml , 30ml
PROLACTIN ANTAGONISTS
Cabergoline 0.5mg/ml , 30ml
Pramipexole Hydrochloride 1mg/ml , 60ml
A.G.E. INHIBITORS / BREAKERS
ALT-711 (thiazolium chloride), 15g
Aminoguanidine HCL 75mg/ml , 60ml
TELOMERASE ACTIVATORS
Astragaloside IV 20mg/ml , 60ml
Cycloastragenol 5mg/ml , 60ml
HEPATOXICITY INHIBITORS
Silibinin 100mg/ml , 60ml
Ursodeoxycholic Acid, 30g
COMBINATION SPECIALS
AICAR KIT + GW1516
Clen + Keto + Yohimbine
Tamox / Clom / Anast
MISCELLANEOUS
Custom Order: CO_061013NH
Foreign Reship Fee
Legal Disclaimer for Download
Priority Shipping
Special Handling Fee $16
Special Handling Fee $30
test

Pramipexole Hydrochloride 1mg/ml , 60ml

 [PX60]
 $55.00 
Pramipexole Hydrochloride 1mg/ml , 60ml

Pramipexole

Pramipexole is a dopamine receptor agonist with affinity for D2S, D2L, D3, and D4 receptors.[1,2]  Officially pramipexole is indicated for prescription to treat Parkinson's disease and Restless Legs Syndrome.[3]  Pramipexole has also been used off-label with reported success to treat sexual dysfunction stemming from SSRI (selective serotonin reuptake inhibitor) use as well as cluster headache and bipolar disorder.[4,5] Further, pilot studies utilizing control groups have demonstrated a statistically significant effect in treating bipolar disorder.[5]

 

A German study suggests that pramipexole is effective in treating depression occurring concurrent with Parkinson's disease when pramipexole is indicated in the treatment of Parkinsonian tremors.[6]

 

In a comprehensive review of extant literature in 2007, Aiken writes that:

The pooled discontinuation rate for all reasons was 9%. Pramipexole is neuroprotective and exerts beneficial effects on sleep architecture. Pramipexole is associated with 3 rare but serious side effects: sleep attacks, which have only occurred in Parkinson's disease; compulsive behaviors and pathologic gambling, which have occurred in Parkinson's disease and restless legs syndrome; and psychosis, which has occurred in both psychiatric and neurologic populations... Pramipexole is an important therapeutic option for treatment-resistant bipolar and unipolar depression; further studies are warranted to evaluate its safety in psychiatric patients.[7]

 

Pramipexole is also useful in neuroprotection applications for individuals with Parkinson's disease.  Neuroprotection is "halting or slowing of the progression of neurodegeneration. Neuroprotective properties of dopamine agonists may be mediated via several mechanisms, (levodopa-sparing effect, decreased dopamine turnover, antioxidant activity or inhibition of the subthalamic nucleus). Many preclinical studies demonstrate that bromocriptine, pergolide, pramipexole, ropinirole and other dopamine agonists provide significant protection against neuronal loss in experimental models."[8]  Since elderly individuals sometimes experience Parkinson's-like symptoms in old age, pramipexole might be indicated for Parkinson's-like cognitive decline and neurodegeneration, or even prevention of such symptoms, in individuals who do not actually have Parkinson's.  Selegiline is a substance with a similar potential for prevention/neuroprotection, with a similar set of issues arising from the mindsets of prescribing physicians and dominant medical perspectives.

 

Citations

[1]Kvernmo T, Hartter S, Burger E. A review of the receptor-binding and pharmacokinetic properties of dopamine agonists". Clinical Therapeutics 28 (8): 1065–78.

[2]Newman-Tancredi A, Cussac D, Audinot V, et al. Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. Agonist and antagonist properties at subtypes of dopamine D(2)-like receptor and alpha(1)/alpha(2)-adrenoceptor. J Pharm and Exp Therapeutics 303 (2): 805–14.

[3]National Prescribing Service. "Pramipexole for Parkinson's Disease". Medicines Update (2009). NPS.ORG

[4]DeBattista C, Solvason HB, Breen JA, Schatzberg AF. (2000). "Pramipexole augmentation of a selective serotonin reuptake inhibitor in the treatment of depression.". J Clin Psychopharmacol. 20 (2): 274–275.

[5]Zarate CA Jr, Payne JL, Singh J, Quiroz JA, Luckenbaugh DA, Denicoff KD, Charney DS, Manji HK.  Pramipexole for bipolar II depression: a placebo-controlled proof of concept study. Biol Psychiatry. 2004 Jul 1;56(1):54-60.

[6]"Dopamine agonist is effective in Parkinson disease not only against tremor. Depression is also improved." MMW Fortschr Med. 2002 May 6;Suppl 2:88.

[7Aiken CB. Pramipexole in psychiatry: a systematic review of the literature. J Clin Psychiatry. 2007 Aug;68(8):1230-6.

[8]Szczudlik A, Rudzińska M. "Neuroprotective effect of dopamine agonists". Neurol Neurochir Pol. 2007 Mar-Apr;41(2 Suppl 1):S22-8.

 

*The latter article is intended for educational / informational purposes only. THIS PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. Bodily introduction of any kind into humans or animals is strictly forbidden by law.

This product was added to our catalog on Friday 06 March, 2009.
Reviews Add to Wish List
Quantity:     
Shopping Cart
  Now in your cart 0 items
 
Your Account
 
Your Email Address
Your Password
 
Information
   
BestSellers
   
Featured
 
  SARMs S4 - 25mg/ml , 60ml
 
 

SARMs S4 - 25mg/ml , 60ml

$139.00
Comments
 
  Toremifene Citrate 60mg/ml , 30ML
 
 

Toremifene Citrate 60mg/ml , 30ML

Amazing company.Amazing product....
$139.00
Who's Online
  There currently are 78 guests and 
2 members online.